UniProt O15151
Protein Mdm4 (O15151)
Protein Mdm4 (UniProt O15151): 62 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15151
- Protein
- Protein Mdm4
- Experimental structures
- 62
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 3 · 1 record with a druggable one
Structures
63 records of O15151 in the MolNFT archive: 62 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CR8 | Solution structure of the zf-RanBP domain of p53-binding protein Mdm4 | solution nmr | A | — | — |
| 2CR8 | Solution structure of the zf-ranbp domain of P53-binding protein MDM4 | solution nmr | A | — | — |
| 2MWY | Mdmx-p53 | solution nmr | A | — | — |
| 2MWY | MDMX-P53 | solution nmr | A | — | — |
| 2N06 | Mdmx-298 | solution nmr | A | — | — |
| 2N06 | MDMX-298 | solution nmr | A | — | — |
| 2N0U | Mdmx-057 | solution nmr | A | — | — |
| 2N0U | MDMX-057 | solution nmr | A | — | — |
| 2N0W | Mdmx-SJ212 | solution nmr | A | — | — |
| 2N0W | MDMX-SJ212 | solution nmr | A | — | — |
| 2N14 | Mdmx-295 | solution nmr | A | — | — |
| 2N14 | MDMX-295 | solution nmr | A | — | — |
| 2VJE | Crystal Structure of the MDM2-MDMX RING Domain Heterodimer | x-ray diffraction | B, D | — | — |
| 2VJE | Crystal structure of the MDM2-mdmx ring domain heterodimer | x-ray diffraction | B, D | — | — |
| 2VJF | Crystal Structure of the MDM2-MDMX RING Domain Heterodimer | x-ray diffraction | B, D | — | — |
| 2VJF | Crystal structure of the MDM2-mdmx ring domain heterodimer | x-ray diffraction | B, D | — | — |
| 2VYR | Structure of human MDM4 N-terminal domain bound to a single domain antibody | x-ray diffraction | A, B, C, D | — | — |
| 2VYR | Structure of human MDM4 N-terminal domain bound to a single domain antibody | x-ray diffraction | A, B, C, D | — | — |
| 3DAB | Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain | x-ray diffraction | A, C, E, G | — | — |
| 3DAB | Structure of the human mdmx protein bound to the P53 tumor suppressor transactivation domain | x-ray diffraction | A, C, E, G | — | — |
| 3EQY | Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor | x-ray diffraction | A, B | — | — |
| 3EQY | Crystal structure of human mdmx in complex with a 12-mer peptide inhibitor | x-ray diffraction | A, B | — | — |
| 3FDO | Structure of human MDMX in complex with high affinity peptide | x-ray diffraction | A | — | — |
| 3FDO | Structure of human mdmx in complex with high affinity peptide | x-ray diffraction | A | — | — |
| 3FE7 | Crystal Structure of HdmX bound to the p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2… | x-ray diffraction | A | — | — |
| 3FE7 | Crystal structure of hdmx bound to the P53-peptidomimetic ac-phe-met- aib-pmp-TRP-glu-AC3C-leu-NH2… | x-ray diffraction | A | — | — |
| 3FEA | Crystal Structure of HdmX bound to the p53-peptidomimetic… | x-ray diffraction | A | — | — |
| 3FEA | Crystal structure of hdmx bound to the P53-peptidomimetic ac-phe-met… | x-ray diffraction | A | — | — |
| 3JZO | Human MDMX liganded with a 12mer peptide (pDI) | x-ray diffraction | A | — | — |
| 3JZO | Human mdmx liganded with a 12MER peptide (pdi) | x-ray diffraction | A | — | — |
| 3JZP | Human MDMX liganded with a 12mer peptide inhibitor (pDI6W) | x-ray diffraction | A | — | — |
| 3JZP | Human mdmx liganded with a 12MER peptide inhibitor (PDI6W) | x-ray diffraction | A | — | — |
| 3JZQ | Human MDMX liganded with a 12mer peptide inhibitor (pDIQ) | x-ray diffraction | A, B | — | — |
| 3JZQ | Human mdmx liganded with a 12MER peptide inhibitor (pdiq) | x-ray diffraction | A, B | — | — |
| 3LBJ | Structure of human MDMX protein in complex with a small molecule inhibitor | x-ray diffraction | E | — | — |
| 3LBJ | Structure of human mdmx protein in complex with a small molecule inhibitor | x-ray diffraction | E | — | — |
| 3U15 | Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443 | x-ray diffraction | A, B, C, D | — | — |
| 3U15 | Structure of hdmx with dimer inducing indolyl hydantoin ro-2443 | x-ray diffraction | A, B, C, D | — | — |
| 4RXZ | Crystal Structure of MDMX phosporylated Tyr99 in complex with a 12-mer peptide | x-ray diffraction | A, B | — | — |
| 4RXZ | Crystal structure of mdmx phosporylated TYR99 in complex with a 12-mer peptide | x-ray diffraction | A, B | — | — |
| 5MNJ | Structure of MDM2-MDMX-UbcH5B-ubiquitin complex | x-ray diffraction | D, H | ZN, SO4 | — |
| 5MNJ | Structure of MDM2-mdmx-UBCH5B-ubiquitin complex | x-ray diffraction | D, H | ZN, SO4 | — |
| 5UML | Crystal structure of human mdmx in complex with 12-mer peptide inhibitor M3 | x-ray diffraction | A, B, E, G | — | — |
| 5UML | Crystal structure of human mdmx in complex with 12-mer peptide inhibitor M3 | x-ray diffraction | A, B, E, G | — | — |
| 5VK1 | Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate… | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 5VK1 | Crystal structure of human MDM4 in complex with a 12-mer lysine- cysteine side chain… | x-ray diffraction | A, C, E, G, I, K, M, O | NH2, ACE | — |
| 6Q9Q | Hdmx (14-111; C17S) complexed with compound 13 at 2.1A; structural states of HDM2 and hdmx: X-ray… | x-ray diffraction | A, B, C, D | HUE, O4B, SO4 | — |
| 6Q9S | Hdmx (14-111; C17S) complexed with compound 14 at 2.4A: structural states of HDM2 and hdmx: X-ray… | x-ray diffraction | A, C, B | HRN, O4B, SO4, NA | — |
| 6Q9U | HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 12 AT 2.4A; Structural states of Hdm2 and HdmX: X-ray… | x-ray diffraction | A | HRE, O4B, CL | — |
| 6Q9U | Hdmx (14-111; C17S) complexed with compound 12 at 2.4A; structural states of HDM2 and hdmx: X-ray… | x-ray diffraction | A | HRE, O4B, CL | — |
| 6Q9W | X-ray structure of compound 15 bound to HdmX: Structural states of Hdm2 and HdmX: X-ray elucidation… | x-ray diffraction | A, B | HRT, SO4, O4B | 3 (best 0.54) |
| 6Q9W | X-ray structure of compound 15 bound to hdmx: structural states of HDM2 and hdmx: X-ray elucidation… | x-ray diffraction | A, B | HRT, SO4, O4B | — |
| 6Q9Y | Hdmx (14-111; C17S) complexed with compound 16 at 1.20A; structural states of HDM2 and hdmx: X-ray… | x-ray diffraction | A, B | HRQ | — |
| 6YR5 | 14-3-3 sigma in complex with hdmx-367 peptide | x-ray diffraction | O, P, Q, R | — | — |
| 6YR7 | 14-3-3 sigma in complex with hdmx-342+367 peptide | x-ray diffraction | Q, C | — | — |
| 7C3Q | Human MdmX protein in complex with Nutlin3a | x-ray diffraction | A | O4B, NUT | — |
| 7C3Q | Human mdmx protein in complex with NUTLIN3A | x-ray diffraction | A | O4B, NUT | — |
| 7C3Y | Crystal structure of the N-terminal domain of human mdmx protein in complex with NUTLIN3A | x-ray diffraction | A | O4B, NUT | — |
| 7C44 | Crystal structure of the P53-binding domain of human mdmx protein in complex with NUTLIN3A | x-ray diffraction | A | NUT, O4B | — |
| 7EL4 | The crystal structure of P53P peptide fragment in complex with the N- terminal domain of mdmx | x-ray diffraction | A | O4B, MG | — |
3 records more on the page itself.
Ligands
- O4B · 1,4,7,10,13,16-hexaoxacyclooctadecane · in 11 records
- SO4 · Sulfate ion · in 6 records
- NUT · 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one · in 4 records
- ZN · Zinc ion · in 3 records
- CL · Chloride ion · in 2 records
- HRE · 4-[(4~{S})-5-(5-chloranyl-2-oxidanylidene-1~{H}-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxy-pyrimidin-5-yl]-6-oxidanylidene-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-4-yl]benzenecarbonitrile · in 2 records
- HRT · (4~{S})-4-(4-chlorophenyl)-5-[(1~{S})-1-(3-chlorophenyl)ethyl]-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-d]imidazol-6-one · in 2 records
- ACE · Acetyl group · in 1 record
- HRN · 3-[[6-chloranyl-3-[3-[(1~{S})-1-(2,4-dichlorophenyl) ethyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]carbonylamino]-4-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]benzoic acid · in 1 record
- HRQ · 7-methoxy-~{N}-[(3~{S})-1-(4-methylphenyl)pyrrolidin-3-yl]-1~{H}-indole-3-carboxamide · in 1 record
- HUE · 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-(4-cyclohexylpiperazin-1-yl)ethyl]-1~{H}-indole-2-carboxamide · in 1 record
- MG · Magnesium ion · in 1 record
- NA · Sodium ion · in 1 record
- NH2 · Amino group · in 1 record
Experiment against prediction
- 3JZQ chain A against the predicted model O15151: TM-score 0.99, RMSD 0.41 Å
- 3JZQ chain A against the predicted model O15151: TM-score 0.99, RMSD 0.41 Å
- 5VK1 chain C against the predicted model O15151: TM-score 0.98, RMSD 0.40 Å
- 5VK1 chain C against the predicted model O15151: TM-score 0.98, RMSD 0.40 Å
- 3FE7 chain A against the predicted model O15151: TM-score 0.98, RMSD 0.42 Å
- 3FE7 chain A against the predicted model O15151: TM-score 0.98, RMSD 0.42 Å
- 3FEA chain A against the predicted model O15151: TM-score 0.98, RMSD 0.43 Å
- 3FEA chain A against the predicted model O15151: TM-score 0.98, RMSD 0.43 Å
- 2VYR chain A against the predicted model O15151: TM-score 0.98, RMSD 0.44 Å
- 2VYR chain A against the predicted model O15151: TM-score 0.98, RMSD 0.44 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.