GL1X · GenesisL1 explorer

Ligand · NUT

NUT · 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one

NUT, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one (C30 H30 Cl2 N4 O4, 581.5 g/mol), in the MolNFT structures on GenesisL1: bound in 11 records (7 PDB…

Component
NUT
Formula
C30 H30 Cl2 N4 O4
Class
ligand
Structures
11
PDB entries
7

Binding sites

NUT in 11 structures; the first of them:

  • 5C5A · Crystal Structure of HDM2 in complex with Nutlin-3a · NUT A201 · binds LEU54, LEU57, GLY58, GLN59, ILE61, MET62, GLN72, HIS73 and 8 more
  • 5ZXF · The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a · NUT A101 · binds LEU33, LEU36, GLY37, GLN38, ILE40, MET41, TYR46, GLN51 and 8 more
  • 7C3Q · Human MdmX protein in complex with Nutlin3a · NUT A202 · binds MET52, LEU55, GLY56, ILE59, MET60, GLN70, HIS71, VAL73 and 5 more
  • 7C3Y · Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a · NUT A202 · binds MET52, LEU55, GLY56, ILE59, MET60, TYR65, GLN70, HIS71 and 6 more
  • 7C44 · Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a · NUT A201 · binds MET52, LEU55, GLY56, ILE59, MET60, TYR65, GLN70, HIS71 and 6 more
  • 8HDG · Small peptide enhances the binding of nutline-3a to MdmX · NUT D201 · binds MET53, LEU56, GLY57, ILE60, MET61, TYR66, GLN71, HIS72 and 6 more
  • 5Z02 · Crystal structure of HIS6-tagged MDM2 with nutlin-3A · NUT A101 · binds LEU33, GLY37, ILE40, MET41, GLN51, HIS52, PHE65, VAL72 and 3 more
  • 5ZXF · The 1.25A crystal structure of HIS6-tagged MDM2 in complex with nutlin-3A · NUT A101 · binds LEU33, GLY37, ILE40, MET41, GLN51, HIS52, PHE65, VAL72 and 3 more
  • 7C3Q · Human mdmx protein in complex with NUTLIN3A · NUT A202 · binds MET52, LEU55, GLY56, ILE59, MET60, GLN70, HIS71, VAL73 and 5 more
  • 7C3Y · Crystal structure of the N-terminal domain of human mdmx protein in complex with NUTLIN3A · NUT A202 · binds MET52, LEU55, GLY56, ILE59, MET60, GLN70, HIS71, VAL73 and 5 more
  • 7C44 · Crystal structure of the P53-binding domain of human mdmx protein in complex with NUTLIN3A · NUT A201 · binds MET52, LEU55, GLY56, ILE59, MET60, GLN70, HIS71, VAL73 and 4 more

Residues it binds most

LEU 15, VAL 15, MET 15, TYR 15, HIS 15, ILE 15, GLN 15, PHE 14, GLY 15, PRO 10 (residue and the binding sites it lines).

Found with

  • O4B · 1,4,7,10,13,16-hexaoxacyclooctadecane
  • PEG · Di(hydroxyethyl)ether
  • CL · Chloride ion
  • IOD · Iodide ion
  • SO4 · Sulfate ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.