Crystal structure of bromodomain 1 of mouse BRD4 in complex with histone H3-K(AC)14

Structure

x-ray diffraction · 2 distinct chains · 51% helix, 0% strand (DSSP).

Ligands and binding sites

• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–C · 259 Ų buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

• 3JVK · Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14 · the same entry in another collection · chain A against A, TM-score 1.00
• Q9ESU6 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (Q9ESU6) · a predicted model of the same protein · chain A against A, TM-score 0.96
• P84243 · AlphaFold monomer V2.0 prediction for histone H3.3 (P84243) · a predicted model of the same protein · chain C against A, TM-score 0.68

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9ESU6
• Every structure of UniProt P84243
• Elsewhere: RCSB PDB 3JVK · PDBe 3JVK · UniProt Q9ESU6 · UniProt P84243