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INSULIN'S biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus

Analyse INSULIN'S biosynthesis and activity have opposing structural requirements: a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3JSD
Type: protein
Length: 102 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin a chain; Insulin B chain
UniProt: P01308
Ligands: IPH, ZN, CL

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin a chain	protein	21	52% helix, 5% strand	P01308
B, D	Insulin B chain	protein	30	40% helix, 10% strand	P01308

Ligands and binding sites

IPH · Phenol · ligand · chains C, D
ZN · Zinc ion · metal · 2 copies · chains B, D
CL · Chloride ion · ion · 2 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

A–B · 882 Å² buried · 9 hydrogen bonds · protein-protein
C–D · 625 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 622 Å² buried · 9 hydrogen bonds · protein-protein
A–D · 60 Å² buried · 1 hydrogen bond · protein-protein
B–C · 28 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide, 2 d-amino (disulfide, D-amino acid).

Compared structures

3JSD · Insulin's biosynthesis and activity have opposing structural requirements: a new factor… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 3JSD · PDBe 3JSD · UniProt P01308

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