Research workbench
Crystal structure of the complex formed between phospholipase A2 and a hexapeptide fragment of amyloid beta peptide, lys-leu-val-phe-phe-ala at 1.2 a resolution
Analyse Crystal structure of the complex formed between phospholipase A2 and a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3JQL
- Type
- protein
- Length
- 125 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase A2 isoform 3; Amyloid beta peptide
- EC
- 3.1.1.4
- UniProt
- P60045
- Ligands
- CA
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phospholipase A2 isoform 3 (EC 3.1.1.4) | protein | 119 | 48% helix, 9% strand | P60045 |
| B | Amyloid beta peptide | protein | 6 | 0% helix, 0% strand | — |
Ligands and binding sites
- CA · Calcium ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 447 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 3JQL · Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide… · the same entry in another collection · chain A against A, TM-score 1.00
- P60045 · AlphaFold monomer V2.0 prediction for acidic phospholipase A2 3 (P60045) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60045
- Elsewhere: RCSB PDB 3JQL · PDBe 3JQL · UniProt P60045
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