Research workbench
3.6 ångström resolution mavs filament generated from helical reconstruction
Analyse 3.6 ångström resolution mavs filament generated from helical reconstruction in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3J6J
- Type
- protein
- Length
- 776 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial antiviral-signaling protein
- UniProt
- Q7Z434
- Pockets
- 9 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, G, I, L | Mitochondrial antiviral-signaling protein | protein | 97 | 73% helix, 0% strand | Q7Z434 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1124 | 0.88 | 0.90 | 98 | empty |
| 2 | 603 | 0.73 | 0.80 | 70 | empty |
| 3 | 341 | 0.59 | 0.77 | 42 | empty |
| 4 | 306 | 0.58 | 0.77 | 43 | empty |
| 5 | 178 | 0.52 | 0.78 | 25 | empty |
Interfaces
22 interfaces between chains.
- B–C · 420 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 400 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 377 Ų buried · 0 hydrogen bonds · protein-protein
- C–G · 373 Ų buried · 1 hydrogen bond · protein-protein
- D–I · 372 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3J6J · 3.6 Angstrom resolution MAVS filament generated from helical reconstruction · the same entry in another collection · chain L against L, TM-score 1.00
- Q7Z434 · AlphaFold monomer V2.0 prediction for mitochondrial antiviral- signaling protein (Q7Z434) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z434
- Elsewhere: RCSB PDB 3J6J · PDBe 3J6J · UniProt Q7Z434
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