Research workbench
Conformational shift of a major poliovirus antigen confirmed by immuno-cryogenic electron microscopy: 135S poliovirus and C3-Fab complex
Analyse Conformational shift of a major poliovirus antigen confirmed by… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3J3P
- Type
- protein
- Length
- 1,163 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C3 antibody, light chain; C3 antibody, heavy chain; Protein VP1; Protein VP2; Protein VP3
- UniProt
- P03300
- Pockets
- 3 · best druggability 0.34
Structure
electron microscopy · 5 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | C3 antibody, light chain | protein | 219 | 0% helix, 0% strand | — |
| H | C3 antibody, heavy chain | protein | 220 | 0% helix, 0% strand | — |
| 1 | Protein VP1 | protein | 243 | 0% helix, 0% strand | P03300 |
| 2 | Protein VP2 | protein | 251 | 0% helix, 0% strand | P03300 |
| 3 | Protein VP3 | protein | 230 | 0% helix, 0% strand | P03300 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.34 | 0.72 | 20 | empty |
| 2 | 65 | 0.31 | 0.73 | 20 | empty |
| 3 | 56 | 0.29 | 0.72 | 23 | empty |
Interfaces
6 interfaces between chains.
- 1–3 · 448 Ų buried · 0 hydrogen bonds · protein-protein
- 2–3 · 283 Ų buried · 0 hydrogen bonds · protein-protein
- 1–2 · 155 Ų buried · 0 hydrogen bonds · protein-protein
- L–H · 86 Ų buried · 0 hydrogen bonds · protein-protein
- H–1 · 80 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3J3P · Conformational Shift of a Major Poliovirus Antigen Confirmed by Immuno-Cryogenic Electron… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03300
- Elsewhere: RCSB PDB 3J3P · PDBe 3J3P · UniProt P03300
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