Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 7% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 1000 Ų buried · 19 hydrogen bonds · protein-protein

Compared structures

• 3IXE · Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin… · the same entry in another collection · chain A against A, TM-score 1.00
• Q13418 · AlphaFold monomer V2.0 prediction for integrin-linked protein kinase (Q13418) · a predicted model of the same protein · chain A against A, TM-score 0.95
• Q7Z4I7 · AlphaFold monomer V2.0 prediction for lim and senescent cell antigen- like-containing… · a predicted model of the same protein · chain B against A, TM-score 0.82

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q13418
• Every structure of UniProt Q7Z4I7
• Elsewhere: RCSB PDB 3IXE · PDBe 3IXE · UniProt Q13418 · UniProt Q7Z4I7