Research workbench
Crystal structure of camp-dependent protein kinase a regulatory subunit I alpha in complex with dual-specific a- kinase anchoring protein 2
Analyse Crystal structure of camp-dependent protein kinase a regulatory subunit I alpha… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3IM4
- Type
- protein
- Length
- 126 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase type I-alpha regulatory subunit; Dual specificity a…
- UniProt
- P00514, O43572
- Ligands
- ZN
Structure
x-ray diffraction · 3 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase type I-alpha regulatory subunit | protein | 50 | 80% helix, 0% strand | P00514 |
| B | Camp-dependent protein kinase type I-alpha regulatory subunit | protein | 49 | 80% helix, 0% strand | P00514 |
| C | Dual specificity a kinase-anchoring protein 2 | protein | 27 | 93% helix, 0% strand | O43572 |
Ligands and binding sites
- ZN · Zinc ion · metal · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
3 interfaces between chains.
- A–B · 1318 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 588 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 471 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3IM4 · Crystal structure of cAMP-dependent Protein Kinase A Regulatory Subunit I alpha in… · the same entry in another collection · chain A against A, TM-score 1.00
- P00514 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type I-alpha… · a predicted model of the same protein · chain B against A, TM-score 0.85
- O43572 · AlphaFold monomer V2.0 prediction for a-kinase anchor protein 10, mitochondrial (O43572) · a predicted model of the same protein · chain C against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00514
- Every structure of UniProt O43572
- Elsewhere: RCSB PDB 3IM4 · PDBe 3IM4 · UniProt P00514 · UniProt O43572
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