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Crystal structure of rabbit ryanodine receptor 1 N-terminal domain (9- 205)
Analyse Crystal structure of rabbit ryanodine receptor 1 N-terminal domain (9- 205) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ILA
- Type
- protein
- Length
- 1,394 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ryanodine receptor 1
- UniProt
- P11716
- Pockets
- 14 · best druggability 0.70
Structure
x-ray diffraction · 9 distinct chains · 8% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ryanodine receptor 1 | protein | 164 | 9% helix, 46% strand | P11716 |
| B | Ryanodine receptor 1 | protein | 160 | 10% helix, 48% strand | P11716 |
| C | Ryanodine receptor 1 | protein | 162 | 8% helix, 50% strand | P11716 |
| D | Ryanodine receptor 1 | protein | 162 | 7% helix, 45% strand | P11716 |
| E | Ryanodine receptor 1 | protein | 156 | 7% helix, 48% strand | P11716 |
| F | Ryanodine receptor 1 | protein | 162 | 6% helix, 47% strand | P11716 |
| G | Ryanodine receptor 1 | protein | 160 | 5% helix, 47% strand | P11716 |
| H | Ryanodine receptor 1 | protein | 159 | 9% helix, 47% strand | P11716 |
| I | Ryanodine receptor 1 | protein | 109 | 6% helix, 45% strand | P11716 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1004 | 0.70 | 0.74 | 77 | empty |
| 2 | 254 | 0.59 | 0.79 | 30 | empty |
| 3 | 308 | 0.57 | 0.77 | 39 | empty |
| 4 | 218 | 0.57 | 0.79 | 36 | empty |
| 5 | 277 | 0.55 | 0.76 | 32 | empty |
Interfaces
14 interfaces between chains.
- B–H · 353 Ų buried · 7 hydrogen bonds · protein-protein
- H–I · 353 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 347 Ų buried · 5 hydrogen bonds · protein-protein
- D–E · 319 Ų buried · 3 hydrogen bonds · protein-protein
- A–E · 316 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3ILA · Crystal structure of rabbit ryanodine receptor 1 N-terminal domain (9-205) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11716
- Elsewhere: RCSB PDB 3ILA · PDBe 3ILA · UniProt P11716
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