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Crystal structure of mouse BCL-xl mutant (R139A) at pH 5.0

Analyse Crystal structure of mouse BCL-xl mutant (R139A) at pH 5.0 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3IHF
Type: protein
Length: 608 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BCL-2-like protein 1
UniProt: Q64373
Pockets: 6 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	BCL-2-like protein 1	protein	152	69% helix, 0% strand	Q64373

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	364	0.69	0.82	39	empty
2	401	0.67	0.80	39	empty
3	87	0.35	0.75	17	empty
4	72	0.31	0.74	17	empty
5	69	0.28	0.72	16	empty

Interfaces

3 interfaces between chains.

B–D · 645 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 635 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 392 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

3IHF · Crystal structure of mouse Bcl-xl mutant (R139A) at pH 5.0 · the same entry in another collection · chain D against D, TM-score 1.00
Q64373 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q64373) · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64373
Elsewhere: RCSB PDB 3IHF · PDBe 3IHF · UniProt Q64373

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