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Catalytic core component of the alkylhydroperoxide reductase ahpf from E.COLI

Analyse Catalytic core component of the alkylhydroperoxide reductase ahpf from E.COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1FL2
Type
protein
Length
310 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Alkyl hydroperoxide reductase subunit F
EC
1.8.1.-
UniProt
P35340
Ligands
FAD, SO4
Pockets
1 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 31% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AAlkyl hydroperoxide reductase subunit F (EC 1.8.1.-)protein31026% helix, 31% strandP35340

Ligands and binding sites

  • FAD · Flavin-adenine dinucleotide · ligand · chains A
  • SO4 · Sulfate ion · ion · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
18330.780.8195FAD

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 1FL2 · Catalytic core component of the alkylhydroperoxide reductase ahpf from E.COLI · the same entry in another collection · chain A against A, TM-score 1.00
  • P35340 · AlphaFold monomer V2.0 prediction for alkyl hydroperoxide reductase subunit F (P35340) · a predicted model of the same protein · chain A against A, TM-score 0.99

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