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Crystal structure of spectinomycin phosphotransferase, APH(9)-ia, in complex with ADP and spectinomcyin

Analyse Crystal structure of spectinomycin phosphotransferase, APH(9)-ia, in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3I0O
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spectinomycin phosphotransferase
UniProt: O06916
Ligands: ADP, SMI, NI, MG
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spectinomycin phosphotransferase	protein	329	46% helix, 14% strand	O06916

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
SMI · Spectinomycin · ligand · chains A
NI · Nickel (II) ion · metal · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	769	0.72	0.78	75	ADP, SMI, MG

Compared structures

3I0O · Crystal Structure of Spectinomycin Phosphotransferase, APH(9)-Ia, in complex with ADP and… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt O06916
Elsewhere: RCSB PDB 3I0O · PDBe 3I0O · UniProt O06916

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