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Crystal structure of distal N-terminal beta-trefoil domain of ryanodine receptor type 1
Analyse Crystal structure of distal N-terminal beta-trefoil domain of ryanodine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HSM
- Type
- protein
- Length
- 323 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ryanodine receptor 1
- UniProt
- P11716
- Pockets
- 3 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ryanodine receptor 1 | protein | 164 | 8% helix, 43% strand | P11716 |
| B | Ryanodine receptor 1 | protein | 159 | 6% helix, 45% strand | P11716 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.37 | 0.75 | 16 | empty |
| 2 | 74 | 0.36 | 0.77 | 18 | empty |
| 3 | 79 | 0.32 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 436 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3HSM · Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11716
- Elsewhere: RCSB PDB 3HSM · PDBe 3HSM · UniProt P11716
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