Research workbench
Structures of spop-substrate complexes: insights into molecular architectures of btb-CUL3 ubiquitin ligases: SPOPMATHX/BTB/3-box- PUCSBC1
Analyse Structures of spop-substrate complexes: insights into molecular architectures… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HQI
- Type
- protein
- Length
- 590 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Speckle-type poz protein; PUCSBC1
- UniProt
- O43791
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 34% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Speckle-type poz protein | protein | 294 | 33% helix, 30% strand | O43791 |
| B | Speckle-type poz protein | protein | 284 | 35% helix, 31% strand | O43791 |
| C, D | PUCSBC1 | protein | 6 | 0% helix, 17% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1123 | 0.72 | 0.76 | 84 | empty |
| 2 | 157 | 0.51 | 0.79 | 24 | empty |
| 3 | 111 | 0.41 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2587 Ų buried · 36 hydrogen bonds · protein-protein
- B–D · 399 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 358 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3HQI · Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3… · the same entry in another collection · chain A against A, TM-score 1.00
- O43791 · AlphaFold monomer V2.0 prediction for speckle-type poz protein (O43791) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43791
- Elsewhere: RCSB PDB 3HQI · PDBe 3HQI · UniProt O43791
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