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Fhit (fragile histidine triad protein)

Analyse Fhit (fragile histidine triad protein) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1FIT
Type: protein
Length: 126 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fragile histidine protein
UniProt: P49789
Ligands: FRU, SO4
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fragile histidine protein	protein	126	34% helix, 25% strand	P49789

Ligands and binding sites

FRU · beta-D-fructofuranose · sugar · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.37	0.74	23	SO4

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

1FIT · Fhit (fragile histidine triad protein) · the same entry in another collection · chain A against A, TM-score 1.00
P49789 · AlphaFold monomer V2.0 prediction for BIS(5'-adenosyl)-triphosphatase (P49789) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49789
Elsewhere: RCSB PDB 1FIT · PDBe 1FIT · UniProt P49789

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