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Crystal structure of hedgehog-interacting protein (hhip)
Analyse Crystal structure of hedgehog-interacting protein (hhip) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HO4
- Type
- protein
- Length
- 879 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hedgehog-interacting protein
- UniProt
- Q96QV1
- Pockets
- 8 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hedgehog-interacting protein | protein | 437 | 5% helix, 40% strand | Q96QV1 |
| B | Hedgehog-interacting protein | protein | 442 | 6% helix, 37% strand | Q96QV1 |
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 877 | 0.79 | 0.82 | 74 | empty |
| 2 | 793 | 0.79 | 0.82 | 69 | empty |
| 3 | 264 | 0.68 | 0.84 | 37 | empty |
| 4 | 248 | 0.68 | 0.84 | 39 | empty |
| 5 | 248 | 0.56 | 0.78 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1064 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 disulfide, 11 modified (disulfide, engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96QV1
- Elsewhere: RCSB PDB 3HO4 · PDBe 3HO4 · UniProt Q96QV1
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