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Crystal structure of the second bromodomain of human tbp-associated factor RNA polymerase 1-like (TAF1L)

Analyse Crystal structure of the second bromodomain of human tbp-associated factor RNA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HMH
Type: protein
Length: 139 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription initiation factor tfiid 210 kda subunit
UniProt: Q8IZX4
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription initiation factor tfiid 210 kda subunit	protein	139	75% helix, 0% strand	Q8IZX4

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	98	0.46	0.80	22	empty

Compared structures

3HMH · Crystal structure of the second bromodomain of human TBP-associated factor RNA polymerase… · the same entry in another collection · chain A against A, TM-score 1.00
Q8IZX4 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IZX4
Elsewhere: RCSB PDB 3HMH · PDBe 3HMH · UniProt Q8IZX4

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