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Crystal structure of the second SEC63 domain of yeast BRR2

Analyse Crystal structure of the second SEC63 domain of yeast BRR2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3HIB
Type: protein
Length: 309 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-splicing helicase BRR2
EC: 3.6.1.-
UniProt: P32639
Pockets: 4 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-splicing helicase BRR2 (EC 3.6.1.-)	protein	309	39% helix, 18% strand	P32639

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.37	0.75	13	empty
2	70	0.36	0.77	16	empty
3	76	0.34	0.75	22	empty
4	81	0.32	0.74	15	empty

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

3HIB · Crystal structure of the second Sec63 domain of yeast Brr2 · the same entry in another collection · chain A against A, TM-score 1.00
P32639 · AlphaFold monomer V2.0 prediction for pre-mRNA-splicing helicase BRR2 (P32639) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32639
Elsewhere: RCSB PDB 3HIB · PDBe 3HIB · UniProt P32639

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