Research workbench
Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1
Analyse Crystal structure of the tyrosine kinase domain of fibroblast growth factor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FGK
- Type
- protein
- Length
- 550 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FGF receptor 1
- EC
- 2.7.1.112
- UniProt
- P11362
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | FGF receptor 1 (EC 2.7.1.112) | protein | 278 | 41% helix, 14% strand | P11362 |
| B | FGF receptor 1 (EC 2.7.1.112) | protein | 272 | 40% helix, 17% strand | P11362 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 732 | 0.75 | 0.80 | 70 | empty |
| 2 | 599 | 0.67 | 0.77 | 60 | empty |
| 3 | 474 | 0.63 | 0.76 | 56 | empty |
| 4 | 93 | 0.36 | 0.75 | 18 | empty |
| 5 | 54 | 0.25 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 524 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1FGK · Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 · the same entry in another collection · chain A against A, TM-score 1.00
- P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 1FGK · PDBe 1FGK · UniProt P11362
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