Research workbench
Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex with SU5402 inhibitor
Analyse Crystal structure of the tyrosine kinase domain of fibroblast growth factor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FGI
- Type
- protein
- Length
- 555 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FGF receptor 1
- EC
- 2.7.1.112
- UniProt
- P11362
- Ligands
- SU1
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | FGF receptor 1 (EC 2.7.1.112) | protein | 283 | 40% helix, 14% strand | P11362 |
| B | FGF receptor 1 (EC 2.7.1.112) | protein | 272 | 41% helix, 15% strand | P11362 |
Ligands and binding sites
- SU1 · 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 700 | 0.74 | 0.79 | 63 | SU1 |
| 2 | 642 | 0.73 | 0.80 | 65 | empty |
| 3 | 159 | 0.64 | 0.85 | 26 | SU1 |
| 4 | 259 | 0.55 | 0.77 | 41 | empty |
| 5 | 83 | 0.35 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 513 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1FGI · Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in… · the same entry in another collection · chain A against A, TM-score 1.00
- P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 1FGI · PDBe 1FGI · UniProt P11362
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