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Crystal structure of T3-bound thyroid hormone receptor

Analyse Crystal structure of T3-bound thyroid hormone receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3GWS
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thyroid hormone receptor beta
UniProt: P10828
Ligands: T3
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Thyroid hormone receptor beta	protein	246	68% helix, 4% strand	P10828

Ligands and binding sites

T3 · 3,5,3'triiodothyronine · ligand · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	187	0.83	0.97	28	T3
2	99	0.40	0.77	19	empty
3	113	0.39	0.75	18	empty

Modifications

Observed in the structure: 3 modified (artifact).

Compared structures

3GWS · Crystal Structure of T3-Bound Thyroid Hormone Receptor · the same entry in another collection · chain X against X, TM-score 1.00
P10828 · AlphaFold monomer V2.0 prediction for thyroid hormone receptor beta (P10828) · a predicted model of the same protein · chain X against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10828
Elsewhere: RCSB PDB 3GWS · PDBe 3GWS · UniProt P10828

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