Research workbench
Crystal structure of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
Analyse Crystal structure of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3GMB
- Type
- protein
- Length
- 738 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase
- UniProt
- Q988D3
- Ligands
- FAD
- Pockets
- 7 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | protein | 369 | 34% helix, 27% strand | Q988D3 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 980 | 0.81 | 0.83 | 96 | FAD |
| 2 | 1093 | 0.81 | 0.82 | 93 | FAD |
| 3 | 191 | 0.46 | 0.75 | 26 | empty |
| 4 | 220 | 0.46 | 0.74 | 30 | empty |
| 5 | 107 | 0.38 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 721 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 3GMB · Crystal Structure of 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q988D3
- Elsewhere: RCSB PDB 3GMB · PDBe 3GMB · UniProt Q988D3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.