Research workbench
Islet amyloid polypeptide (iapp or amylin) residues 1 to 22 fused to maltose binding protein
Analyse Islet amyloid polypeptide (iapp or amylin) residues 1 to 22 fused to maltose… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3G7W
- Type
- protein
- Length
- 393 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, islet amyloid polypeptide fusion protein
- UniProt
- P0AEX9, P10997
- Ligands
- GLC, SO4
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, islet amyloid polypeptide fusion protein | protein | 393 | 44% helix, 20% strand | P0AEX9, P10997 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 3 copies · chains A
- SO4 · Sulfate ion · ion · 20 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 365 | 0.72 | 0.83 | 31 | GLC |
| 2 | 72 | 0.57 | 0.88 | 20 | empty |
| 3 | 96 | 0.50 | 0.82 | 24 | empty |
| 4 | 105 | 0.42 | 0.77 | 25 | empty |
| 5 | 58 | 0.29 | 0.74 | 17 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3G7W · Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding… · the same entry in another collection · chain A against A, TM-score 1.00
- P10997 · AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P10997) · a predicted model of the same protein · chain A against A, TM-score 0.08
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P10997
- Elsewhere: RCSB PDB 3G7W · PDBe 3G7W · UniProt P0AEX9 · UniProt P10997
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