Research workbench
Vhs domain of human GGA1 complexed with a dxxll hinge peptide
Analyse Vhs domain of human GGA1 complexed with a dxxll hinge peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3G2W
- Type
- protein
- Length
- 294 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ADP-ribosylation factor-binding protein GGA1; Internal peptide of the hinge domain of…
- UniProt
- Q9UJY5
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ADP-ribosylation factor-binding protein GGA1 | protein | 139 | 74% helix, 0% strand | Q9UJY5 |
| B | ADP-ribosylation factor-binding protein GGA1 | protein | 138 | 67% helix, 0% strand | Q9UJY5 |
| C | Internal peptide of the hinge domain of ADP-ribosylation factor-binding protein GGA1 | protein | 9 | 0% helix, 0% strand | Q9UJY5 |
| D | Internal peptide of the hinge domain of ADP-ribosylation factor-binding protein GGA1 | protein | 8 | 0% helix, 0% strand | Q9UJY5 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.71 | 0.81 | 59 | empty |
| 2 | 109 | 0.48 | 0.81 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 692 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 566 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 504 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3G2W · VHS Domain of human GGA1 complexed with a DXXLL hinge peptide · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UJY5 · AlphaFold monomer V2.0 prediction for ADP-ribosylation factor-binding protein GGA1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UJY5
- Elsewhere: RCSB PDB 3G2W · PDBe 3G2W · UniProt Q9UJY5
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