Research workbench
Catalytic domain of the human E3 ubiquitin-protein ligase HUWE1
Analyse Catalytic domain of the human E3 ubiquitin-protein ligase HUWE1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3G1N
- Type
- protein
- Length
- 745 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase HUWE1
- EC
- 6.3.2.-
- UniProt
- Q7Z6Z7
- Ligands
- NA
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) | protein | 374 | 47% helix, 14% strand | Q7Z6Z7 |
| B | E3 ubiquitin-protein ligase HUWE1 (EC 6.3.2.-) | protein | 371 | 49% helix, 15% strand | Q7Z6Z7 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 624 | 0.78 | 0.84 | 59 | empty |
| 2 | 948 | 0.76 | 0.78 | 61 | empty |
| 3 | 447 | 0.70 | 0.81 | 40 | empty |
| 4 | 453 | 0.67 | 0.79 | 38 | empty |
| 5 | 245 | 0.63 | 0.82 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 1473 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 3G1N · Catalytic domain of the human E3 ubiquitin-protein ligase HUWE1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z6Z7
- Elsewhere: RCSB PDB 3G1N · PDBe 3G1N · UniProt Q7Z6Z7
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