Research workbench
Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2- YL)METHYLAMINE
Analyse Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FU5
- Type
- protein
- Length
- 606 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukotriene a-4 hydrolase
- EC
- 3.3.2.6
- UniProt
- P09960
- Ligands
- 492, ZN, YB
- Pockets
- 5 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leukotriene a-4 hydrolase (EC 3.3.2.6) | protein | 606 | 43% helix, 24% strand | P09960 |
Ligands and binding sites
- 492 · 1-(2,2'-bithiophen-5-yl)methanamine · ligand · chains A
- ZN · Zinc ion · metal · chains A
- YB · Ytterbium (III) ion · metal · chains A
- IMD · Imidazole · additive · 2 copies · chains A
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1059 | 0.85 | 0.86 | 96 | 492, IMD |
| 2 | 197 | 0.51 | 0.77 | 27 | empty |
| 3 | 91 | 0.50 | 0.83 | 19 | empty |
| 4 | 61 | 0.36 | 0.78 | 15 | empty |
| 5 | 53 | 0.27 | 0.74 | 14 | empty |
Compared structures
- 3FU5 · Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2-yl)methylamine · the same entry in another collection · chain A against A, TM-score 1.00
- P09960 · AlphaFold monomer V2.0 prediction for leukotriene a-4 hydrolase (P09960) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09960
- Elsewhere: RCSB PDB 3FU5 · PDBe 3FU5 · UniProt P09960
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