Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-D- glucose N-acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with CoA and dtdp-3-amino- quinovose

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 31% strand (DSSP).

Ligands and binding sites

• COA · Coenzyme A · ligand · 2 copies · chains A, B
• T3Q · [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 151 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 3FSB · Crystal structure of QdtC, the dTDP-3-amino-3,6-dideoxy-D-glucose N-acetyl transferase… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q6TFC6
• Elsewhere: RCSB PDB 3FSB · PDBe 3FSB · UniProt Q6TFC6