Research workbench
Phosphorylation of self-peptides alters human leukocyte antigen class I-restricted antigen presentation and generates tumor specific epitopes
Analyse Phosphorylation of self-peptides alters human leukocyte antigen class… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FQX
- Type
- protein
- Length
- 382 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, a-2 alpha chain; Beta-2-microglobulin…
- UniProt
- P01892, P61769
- Ligands
- CD, MG
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, a-2 alpha chain | protein | 275 | 26% helix, 40% strand | P01892 |
| B | Beta-2-microglobulin | protein | 98 | 0% helix, 50% strand | P61769 |
| C | Phospho-peptide 1097-1105 from insulin receptor substrate 2 (IRS2): RVA(SEP)PTSGV | protein | 9 | 0% helix, 0% strand | — |
Ligands and binding sites
- CD · Cadmium ion · metal · 5 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 641 | 0.67 | 0.77 | 67 | CD, GOL |
| 2 | 55 | 0.40 | 0.81 | 15 | empty |
| 3 | 68 | 0.40 | 0.79 | 16 | GOL |
| 4 | 79 | 0.35 | 0.76 | 15 | empty |
| 5 | 70 | 0.35 | 0.76 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1293 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 848 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide, 1 modified (disulfide, phosphorylation).
Compared structures
- 3FQX · Phosphorylation of self-peptides alters Human Leukocyte Antigen Class I-restricted… · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01892
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 3FQX · PDBe 3FQX · UniProt P01892 · UniProt P61769
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