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Low resolution structure of ovine ornithine transcarbmoylase in the unliganded state

Analyse Low resolution structure of ovine ornithine transcarbmoylase in the unliganded… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1FB5
Type: protein
Length: 320 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ornithine transcarbamoylase
EC: 2.1.3.3
UniProt: P00480
Ligands: NVA
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ornithine transcarbamoylase (EC 2.1.3.3)	protein	320	45% helix, 13% strand	P00480

Ligands and binding sites

NVA · Norvaline · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	467	0.66	0.78	48	empty
2	67	0.63	0.92	15	empty

Compared structures

1FB5 · Low resolution structure of ovine ornithine transcarbmoylase in the unliganded state · the same entry in another collection · chain A against A, TM-score 1.00
P00480 · AlphaFold monomer V2.0 prediction for ornithine transcarbamylase, mitochondrial (P00480) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00480
Elsewhere: RCSB PDB 1FB5 · PDBe 1FB5 · UniProt P00480

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