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Ligand · NVA

NVA · Norvaline

NVA, Norvaline (C5 H11 N O2, 117.2 g/mol), in the MolNFT structures on GenesisL1: bound in 22 records (11 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
NVA
Formula
C5 H11 N O2
Class
ligand
Structures
22
PDB entries
11

Binding sites

NVA in 22 structures; the first of them:

  • 1C9Y · Human ornithine transcarbamylase: crystallographic insights into substrate recognition… · NVA A355 · binds ARG141, LEU163, HIS168, ASN198, ASN199, ILE200, ASP263, THR264 and 5 more
  • 1FB5 · Low resolution structure of ovine ornithine transcarbmoylase in the unliganded state · NVA A900 · binds GLY79, SER132, SER133, MET134, ALA135, ASP136
  • 1JDX · Crystal structure of human L-ARGININE:GLYCINE amidinotransferase in complex with… · NVA A500 · binds MET302, HIS303, ASP305, ALA306, ARG322, SER354, SER355, LEU358 and 2 more
  • 1OBC · Leucyl-tRNA synthetase from thermus thermophilus complexed with a post-transfer editing… · NVA A1815 · binds PHE246, THR247, ARG249, THR252, ILE337, MET338, ALA339, VAL340 and 3 more
  • 1OBH · Leucyl-tRNA synthetase from thermus thermophilus complexed with a pre-transfer editing… · NVA A1816 · binds MET40, PHE41, PRO42, TYR43, ASP80, SER504, TYR507, TYR535 and 1 more
  • 2BTE · Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the… · NVA A1892 · binds PHE246, THR247, ARG249, THR252, ILE337, MET338, ALA339, VAL340 and 3 more
  • 2I6U · Crystal Structure of Ornithine Carbamoyltransferase complexed with Carbamoyl Phosphate… · NVA A600 · binds ARG101, LEU123, HIS128, ASN159, ASN160, MET161, ASP224, THR225 and 6 more
  • 4H31 · Crystal structure of anabolic ornithine carbamoyltransferase from Vibrio vulnificus in… · NVA A401 · binds ARG108, LEU130, HIS135, ASN168, ASN169, VAL170, ASP233, VAL234 and 5 more
  • 4NF2 · Crystal structure of anabolic ornithine carbamoyltransferase from Bacillus anthracis in… · NVA A402 · binds ARG108, LEU130, HIS135, ASN165, ASN166, VAL167, ASP230, VAL231 and 6 more
  • 5ZEF · Crystal structure of Entamoeba histolytica Arginase in complex with L- Norvaline at 2.01 A · NVA A301 · binds HIS126, ASP128, ASN130, SER135, PRO136, SER137, HIS141, GLY142 and 3 more
  • 6W3T · Crystal structure of ligand-binding domain of Campylobacter jejuni chemoreceptor Tlp3 in… · NVA A301 · binds ASN116, TYR118, VAL126, LEU128, LEU144, LYS149, TRP151, TYR167 and 7 more
  • 1C9Y · Human ornithine transcarbamylase: crystallographic insights into substrate recognition… · NVA A355 · binds ARG141, LEU163, HIS168, ASN198, ASN199, ILE200, ASP263, THR264 and 5 more
  • 1FB5 · Low resolution structure of ovine ornithine transcarbmoylase in the unliganded state · NVA A900 · binds GLY79, SER132, SER133, MET134, ALA135, ASP136
  • 1JDX · Crystal structure of human L-ARGININE:GLYCINE amidinotransferase in complex with… · NVA A500 · binds MET302, HIS303, ASP305, ALA306, ARG322, SER354, SER355, LEU358 and 2 more
  • 1OBC · Leucyl-tRNA synthetase from thermus thermophilus complexed with a post-transfer editing… · NVA A1815 · binds PHE246, THR247, ARG249, THR252, ILE337, MET338, ALA339, VAL340 and 3 more
  • 1OBH · Leucyl-tRNA synthetase from thermus thermophilus complexed with a pre-transfer editing… · NVA A1816 · binds MET40, PHE41, PRO42, TYR43, ASP80, SER504, TYR507, TYR535 and 1 more
  • 2BTE · Thermus thermophilus leucyl-tRNA synthetase complexed with with a trnaleu transcript in… · NVA A1892 · binds PHE246, THR247, ARG249, THR252, ILE337, MET338, ALA339, VAL340 and 3 more
  • 2I6U · Crystal structure of ornithine carbamoyltransferase complexed with carbamoyl phosphate… · NVA A600 · binds ARG101, LEU123, HIS128, ASN159, ASN160, MET161, ASP224, THR225 and 6 more
  • 4H31 · Crystal structure of anabolic ornithine carbamoyltransferase from vibrio vulnificus in… · NVA A401 · binds ARG108, LEU130, HIS135, ASN168, ASN169, VAL170, ASP233, VAL234 and 5 more
  • 4NF2 · Crystal structure of anabolic ornithine carbamoyltransferase from bacillus anthracis in… · NVA A402 · binds ARG108, LEU130, HIS135, ASN165, ASN166, VAL167, ASP230, VAL231 and 6 more
  • 5ZEF · Crystal structure of entamoeba histolytica arginase in complex with L- norvaline at 2.01 a · NVA A301 · binds HIS126, ASP128, ASN130, SER135, PRO136, SER137, HIS141, GLY142 and 3 more

Residues it binds most

ASP 42, LEU 26, ASN 26, VAL 24, ARG 30, HIS 36, MET 34, SER 30, THR 24, CYS 22 (residue and the binding sites it lines).

Found with

  • CP · Phosphoric acid mono(formamide)ester
  • SO4 · Sulfate ion
  • 2AD · 2'-amino-2'-deoxyadenosine
  • LEU · Leucine
  • LMS · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl sulfamate
  • HG · Mercury (II) ion
  • ZN · Zinc ion
  • CL · Chloride ion
  • GOL · Glycerol
  • MN · Manganese (II) ion
  • EDO · 1,2-ethanediol
  • PE5 · 3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol

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