Research workbench
Quaternary structure of drosophila melanogaster IC/TCTEX-1/LC8; allosteric interactions of dynein light chains with dynein intermediate chain
Analyse Quaternary structure of drosophila melanogaster IC/TCTEX-1/LC8; allosteric… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FM7
- Type
- protein
- Length
- 431 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dynein light chain tctex-type; Dynein intermediate chain, cytosolic; Dynein light chain…
- UniProt
- Q94524, Q24246, Q24117
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 28% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dynein light chain tctex-type | protein | 103 | 28% helix, 35% strand | Q94524 |
| B | Dynein light chain tctex-type | protein | 104 | 28% helix, 32% strand | Q94524 |
| C, D | Dynein intermediate chain, cytosolic | protein | 27 | 0% helix, 41% strand | Q24246 |
| E, F | Dynein light chain 1, cytoplasmic | protein | 85 | 38% helix, 41% strand | Q24117 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.73 | 0.94 | 26 | empty |
| 2 | 122 | 0.72 | 0.92 | 26 | empty |
| 3 | 144 | 0.36 | 0.72 | 24 | empty |
Interfaces
10 interfaces between chains.
- A–B · 1698 Ų buried · 30 hydrogen bonds · protein-protein
- E–F · 923 Ų buried · 27 hydrogen bonds · protein-protein
- B–D · 861 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 856 Ų buried · 18 hydrogen bonds · protein-protein
- C–E · 730 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 3FM7 · Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions… · the same entry in another collection · chain F against F, TM-score 1.00
- Q24117 · AlphaFold monomer V2.0 prediction for dynein light chain 1, cytoplasmic (Q24117) · a predicted model of the same protein · chain E against A, TM-score 0.98
- Q94524 · AlphaFold monomer V2.0 prediction for dynein light chain tctex-type (Q94524) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q24246 · AlphaFold monomer V2.0 prediction for cytoplasmic dynein 1 intermediate chain (Q24246) · a predicted model of the same protein · chain D against A, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94524
- Every structure of UniProt Q24246
- Every structure of UniProt Q24117
- Elsewhere: RCSB PDB 3FM7 · PDBe 3FM7 · UniProt Q94524 · UniProt Q24246 · UniProt Q24117
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