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Crystal structure of sulfolobus solfataricus 8-oxoguanine DNA glycosylase (ssogg)

Analyse Crystal structure of sulfolobus solfataricus 8-oxoguanine DNA glycosylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3FHG
Type
protein
Length
207 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
N-GLYCOSYLASE/DNA lyase
EC
3.2.2.-, 4.2.99.18
UniProt
Q97ZK2
Ligands
SO4
Pockets
1 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AN-GLYCOSYLASE/DNA lyase (EC 3.2.2.-, 4.2.99.18)protein20771% helix, 0% strandQ97ZK2

Ligands and binding sites

  • SO4 · Sulfate ion · ion · 10 copies · chains A
  • GOL · Glycerol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11230.570.8421GOL

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 3FHG · Crystal structure of Sulfolobus solfataricus 8-oxoguanine DNA glycosylase (SsOgg) · the same entry in another collection · chain A against A, TM-score 1.00
  • Q97ZK2 · AlphaFold monomer V2.0 prediction for 8-oxoguanine DNA GLYCOSYLASE/AP lyase (Q97ZK2) · a predicted model of the same protein · chain A against A, TM-score 0.99

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