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HCN2I 443-640 apo-state

Analyse HCN2I 443-640 apo-state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3FFQ
Type: protein
Length: 368 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 2
UniProt: O88703
Ligands: BR
Pockets: 7 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 2	protein	184	51% helix, 21% strand	O88703
B	POTASSIUM/SODIUM hyperpolarization-activated cyclic nucleotide-gated channel 2	protein	184	50% helix, 21% strand	O88703

Ligands and binding sites

BR · Bromide ion · ion · 9 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	206	0.53	0.78	22	empty
2	225	0.48	0.74	23	empty
3	78	0.47	0.82	16	BR
4	85	0.45	0.80	18	BR
5	158	0.45	0.75	32	BR

Interfaces

1 interface between chains.

A–B · 421 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3FFQ · HCN2I 443-640 apo-state · the same entry in another collection · chain A against A, TM-score 1.00
O88703 · AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O88703
Elsewhere: RCSB PDB 3FFQ · PDBe 3FFQ · UniProt O88703

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