UniProt O88703
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (O88703)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (UniProt O88703): 27 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 4 pockets. Binding sites, druggability and…
- UniProt
- O88703
- Protein
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 4 · 2 records with a druggable one
Structures
28 records of O88703 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Q3E | HCN2J 443-645 in the presence of cGMP | x-ray diffraction | A, B | — | — |
| 1Q3E | HCN2J 443-645 in the presence of cgmp | x-ray diffraction | A, B | — | — |
| 1Q43 | HCN2I 443-640 in the presence of cAMP, selenomethionine derivative | x-ray diffraction | A, B | — | — |
| 1Q43 | HCN2I 443-640 in the presence of camp, selenomethionine derivative | x-ray diffraction | A, B | — | — |
| 1Q5O | HCN2J 443-645 in the presence of cAMP, selenomethionine derivative | x-ray diffraction | A | — | — |
| 1Q5O | HCN2J 443-645 in the presence of camp, selenomethionine derivative | x-ray diffraction | A | — | — |
| 2Q0A | Structure and rearrangements in the carboxy-terminal region of SpIH channels | x-ray diffraction | A, B | — | — |
| 2Q0A | Structure and rearrangements in the carboxy-terminal region of spih channels | x-ray diffraction | A, B | — | — |
| 3BPZ | HCN2-I 443-460 E502K in the presence of cAMP | x-ray diffraction | A, B, C, D | — | — |
| 3BPZ | HCN2-I 443-460 E502K in the presence of camp | x-ray diffraction | A, B, C, D | — | — |
| 3ETQ | X-ray structure of cysteine-free fragment of mHCN2 C-terminal region from amino acids 443-630… | x-ray diffraction | A, B | — | — |
| 3ETQ | X-ray structure of cysteine-free fragment of MHCN2 C-terminal region from amino acids 443-630… | x-ray diffraction | A, B | — | — |
| 3FFQ | HCN2I 443-640 apo-state | x-ray diffraction | A, B | — | — |
| 3FFQ | HCN2I 443-640 apo-state | x-ray diffraction | A, B | — | — |
| 4EQF | Trip8b-1a#206-567 interacting with the carboxy-terminal seven residues of HCN2 | x-ray diffraction | B | — | — |
| 4EQF | TRIP8B-1A#206-567 interacting with the carboxy-terminal seven residues of HCN2 | x-ray diffraction | B | — | — |
| 5JON | Crystal structure of the unliganded form of HCN2 cnbd | x-ray diffraction | A, B | — | — |
| 5KHG | HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP) | x-ray diffraction | A | CC7 | — |
| 5KHG | HCN2 cnbd in complex with cytidine-3', 5'-cyclic monophosphate (ccmp) | x-ray diffraction | A | CC7 | — |
| 5KHH | HCN2 CNBD in complex with inosine-3', 5'-cyclic monophosphate (cIMP) | x-ray diffraction | A | 6SW | — |
| 5KHH | HCN2 cnbd in complex with inosine-3', 5'-cyclic monophosphate (cimp) | x-ray diffraction | A | 6SW | — |
| 5KHI | HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP) | x-ray diffraction | A | 6SX | 2 (best 0.68) |
| 5KHI | HCN2 cnbd in complex with purine riboside-3', 5'-cyclic monophosphate (cpump) | x-ray diffraction | A | 6SX | — |
| 5KHJ | HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP) | x-ray diffraction | A, B | 6SY | — |
| 5KHJ | HCN2 cnbd in complex with uridine-3', 5'-cyclic monophosphate (cump) | x-ray diffraction | A, B | 6SY | — |
| 5KHK | HCN2 CNBD in complex with 2-aminopurine riboside-3', 5'-cyclic monophosphate (2-NH2-cPuMP) | x-ray diffraction | A | 6SZ | 2 (best 0.67) |
| 5KHK | HCN2 cnbd in complex with 2-aminopurine riboside-3', 5'-cyclic monophosphate (2-NH2-cpump) | x-ray diffraction | A | 6SZ | — |
| O88703 | AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… | predicted | A | — | — |
Ligands
- 6SW · Inosine-3',5'-cyclic monophosphate · in 2 records
- 6SX · Purine riboside-3',5'-cyclic monophosphate · in 2 records
- 6SY · Uridine-3',5'-cyclic monophosphate · in 2 records
- 6SZ · 2-Aminopurine riboside-3',5'-cyclic monophosphate · in 2 records
- CC7 · 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one · in 2 records
Experiment against prediction
- 3ETQ chain A against the predicted model O88703: TM-score 0.98, RMSD 0.81 Å
- 3ETQ chain A against the predicted model O88703: TM-score 0.98, RMSD 0.81 Å
- 1Q43 chain B against the predicted model O88703: TM-score 0.98, RMSD 0.80 Å
- 1Q43 chain B against the predicted model O88703: TM-score 0.98, RMSD 0.80 Å
- 1Q3E chain B against the predicted model O88703: TM-score 0.98, RMSD 0.82 Å
- 1Q3E chain B against the predicted model O88703: TM-score 0.98, RMSD 0.82 Å
- 1Q3E chain A against the predicted model O88703: TM-score 0.98, RMSD 0.83 Å
- 1Q3E chain A against the predicted model O88703: TM-score 0.98, RMSD 0.83 Å
- 5KHH chain A against the predicted model O88703: TM-score 0.98, RMSD 0.83 Å
- 5KHH chain A against the predicted model O88703: TM-score 0.98, RMSD 0.83 Å
Elsewhere
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