Research workbench
Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody
Analyse Structure of parathyroid hormone-related protein complexed to a neutralizing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FFD
- Type
- protein
- Length
- 445 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoclonal antibody, heavy chain, Fab fragment; Monoclonal antibody, light chain, Fab…
- UniProt
- P12272
- Pockets
- 4 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 11% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monoclonal antibody, heavy chain, Fab fragment | protein | 210 | 9% helix, 50% strand | — |
| B | Monoclonal antibody, light chain, Fab fragment | protein | 217 | 7% helix, 56% strand | — |
| P | Parathyroid hormone-related protein | protein | 18 | 83% helix, 0% strand | P12272 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 647 | 0.64 | 0.74 | 56 | empty |
| 2 | 134 | 0.42 | 0.75 | 26 | empty |
| 3 | 54 | 0.32 | 0.77 | 15 | empty |
| 4 | 62 | 0.28 | 0.73 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1860 Ų buried · 12 hydrogen bonds · protein-protein
- A–P · 562 Ų buried · 12 hydrogen bonds · protein-protein
- B–P · 436 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3FFD · Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal… · the same entry in another collection · chain B against B, TM-score 1.00
- P12272 · AlphaFold monomer V2.0 prediction for parathyroid hormone-related protein (P12272) · a predicted model of the same protein · chain P against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12272
- Elsewhere: RCSB PDB 3FFD · PDBe 3FFD · UniProt P12272
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.