Research workbench
Crystal structure of human il-18 in complex with ectromelia virus il- 18 binding protein
Analyse Crystal structure of human il-18 in complex with ectromelia virus il- 18… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3F62
- Type
- protein
- Length
- 253 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin 18 binding protein; Interleukin-18
- UniProt
- Q9IW12, Q14116
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin 18 binding protein | protein | 108 | 3% helix, 53% strand | Q9IW12 |
| B | Interleukin-18 | protein | 145 | 6% helix, 54% strand | Q14116 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.40 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 992 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3F62 · Crystal Structure of Human IL-18 in complex with Ectromelia virus IL-18 Binding Protein · the same entry in another collection · chain A against A, TM-score 1.00
- Q14116 · AlphaFold monomer V2.0 prediction for interleukin-18 (Q14116) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9IW12
- Every structure of UniProt Q14116
- Elsewhere: RCSB PDB 3F62 · PDBe 3F62 · UniProt Q9IW12 · UniProt Q14116
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