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Crystal structure of clostridium acetobutylicum 8-oxoguanine DNA glycosylase in complex with 8-oxoguanosine

Analyse Crystal structure of clostridium acetobutylicum 8-oxoguanine DNA glycosylase in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3F10
Type: protein
Length: 292 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 8-oxoguanine-DNA-glycosylase
EC: 3.2.2.-, 4.2.99.18
UniProt: Q97FM4
Ligands: 8HG
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	8-oxoguanine-DNA-glycosylase (EC 3.2.2.-, 4.2.99.18)	protein	292	52% helix, 12% strand	Q97FM4

Ligands and binding sites

8HG · 2'-deoxy-8-oxoguanosine · ligand · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	144	0.54	0.81	27	8HG
2	103	0.37	0.75	17	empty

Compared structures

3F10 · Crystal structure of Clostridium Acetobutylicum 8-oxoguanine DNA glycosylase in complex… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q97FM4
Elsewhere: RCSB PDB 3F10 · PDBe 3F10 · UniProt Q97FM4

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