Research workbench
Complex of the amino terminal domain of enzyme I and the histidine- containing phosphocarrier protein hpr from escherichia COLI
Analyse Complex of the amino terminal domain of enzyme I and the histidine- containing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EZB
- Type
- protein
- Length
- 344 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (phosphotransfer system, enzyme I); Protein (phosphocarrier protein hpr)
- EC
- 2.7.3.9
- UniProt
- P08839, P0AA04
- Pockets
- 1 · best druggability 0.71
Structure
solution nmr · 2 distinct chains · 49% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (phosphotransfer system, enzyme I) (EC 2.7.3.9) | protein | 259 | 54% helix, 11% strand | P08839 |
| B | Protein (phosphocarrier protein hpr) | protein | 85 | 34% helix, 27% strand | P0AA04 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 556 | 0.71 | 0.80 | 64 | empty |
Interfaces
1 interface between chains.
- A–B · 1009 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3EZB · Complex of the amino terminal domain of enzyme I and the histidine-containing… · the same entry in another collection · chain B against B, TM-score 1.00
- P0AA04 · AlphaFold monomer V2.0 prediction for phosphocarrier protein hpr (P0AA04) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P08839 · AlphaFold monomer V2.0 prediction for phosphoenolpyruvate-protein phosphotransferase… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08839
- Every structure of UniProt P0AA04
- Elsewhere: RCSB PDB 3EZB · PDBe 3EZB · UniProt P08839 · UniProt P0AA04
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