Research workbench

Crystal structure of the muke-mukf complex

Analyse Crystal structure of the muke-mukf complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3EUH
Type: protein
Length: 1,413 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chromosome partition protein mukf; Muke
UniProt: P60293, Q6ITT5
Ligands: GLY
Pockets: 16 · best druggability 0.83

Structure

x-ray diffraction · 6 distinct chains · 62% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chromosome partition protein mukf	protein	315	72% helix, 8% strand	P60293
B	Chromosome partition protein mukf	protein	321	75% helix, 7% strand	P60293
C	Muke	protein	206	57% helix, 13% strand	Q6ITT5
D	Muke	protein	188	51% helix, 13% strand	Q6ITT5
E	Muke	protein	201	56% helix, 13% strand	Q6ITT5
F	Muke	protein	182	48% helix, 8% strand	Q6ITT5

Ligands and binding sites

GLY · Glycine · ligand · 4 copies · chains A, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1092	0.83	0.84	81	empty
2	55	0.72	0.99	19	empty
3	730	0.71	0.78	76	empty
4	534	0.65	0.77	56	empty
5	281	0.65	0.81	39	empty

Interfaces

9 interfaces between chains.

A–B · 3696 Å² buried · 38 hydrogen bonds · protein-protein
A–C · 2299 Å² buried · 26 hydrogen bonds · protein-protein
B–E · 2219 Å² buried · 27 hydrogen bonds · protein-protein
B–F · 768 Å² buried · 14 hydrogen bonds · protein-protein
E–F · 751 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

3EUH · Crystal Structure of the MukE-MukF Complex · the same entry in another collection · chain F against F, TM-score 1.00
P60293 · AlphaFold monomer V2.0 prediction for chromosome partition protein mukf (P60293) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60293
Every structure of UniProt Q6ITT5
Elsewhere: RCSB PDB 3EUH · PDBe 3EUH · UniProt P60293 · UniProt Q6ITT5

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.