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Crystal structure of PRP8 core domain IV
Analyse Crystal structure of PRP8 core domain IV in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ENB
- Type
- protein
- Length
- 422 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-processing-splicing factor 8
- UniProt
- Q6P2Q9
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-processing-splicing factor 8 | protein | 219 | 42% helix, 20% strand | Q6P2Q9 |
| B | Pre-mRNA-processing-splicing factor 8 | protein | 203 | 41% helix, 17% strand | Q6P2Q9 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 379 | 0.64 | 0.79 | 36 | empty |
| 2 | 314 | 0.61 | 0.78 | 36 | empty |
| 3 | 89 | 0.55 | 0.85 | 24 | empty |
| 4 | 148 | 0.49 | 0.78 | 24 | empty |
| 5 | 118 | 0.43 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1084 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3ENB · Crystal Structure of PRP8 core domain IV · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P2Q9
- Elsewhere: RCSB PDB 3ENB · PDBe 3ENB · UniProt Q6P2Q9
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