Ribosomal protein L11 methyltransferase (prma) in complex with trimethylated ribosomal protein L11

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 32% strand (DSSP).

Ligands and binding sites

• 4MM · N,N,N-trimethylmethionine · ligand · chains A, B
• SAH · S-adenosyl-L-homocysteine · ligand · chains A, B
• CL · Chloride ion · ion · chains A, B
• IOD · Iodide ion · ion · chains A, B
• GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1486 Ų buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 3EGV · Ribosomal protein L11 methyltransferase (PrmA) in complex with trimethylated ribosomal… · the same entry in another collection · chain B against B, TM-score 1.00
• Q84BQ9 · AlphaFold monomer V2.0 prediction for ribosomal protein L11 methyltransferase (Q84BQ9) · a predicted model of the same protein · chain A against A, TM-score 0.99
• Q5SLP6 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L11 (Q5SLP6) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q84BQ9
• Every structure of UniProt Q5SLP6
• Elsewhere: RCSB PDB 3EGV · PDBe 3EGV · UniProt Q84BQ9 · UniProt Q5SLP6