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Crystal structure of human translationally controlled tumour associated protein (htctp) mutant E12V
Analyse Crystal structure of human translationally controlled tumour associated protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EBM
- Type
- protein
- Length
- 583 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translationally-controlled tumor protein
- UniProt
- P13693
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translationally-controlled tumor protein | protein | 147 | 37% helix, 31% strand | P13693 |
| B | Translationally-controlled tumor protein | protein | 147 | 36% helix, 32% strand | P13693 |
| C | Translationally-controlled tumor protein | protein | 145 | 39% helix, 33% strand | P13693 |
| D | Translationally-controlled tumor protein | protein | 144 | 33% helix, 32% strand | P13693 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.70 | 0.90 | 24 | empty |
| 2 | 400 | 0.67 | 0.80 | 33 | empty |
| 3 | 244 | 0.63 | 0.81 | 29 | empty |
| 4 | 140 | 0.56 | 0.82 | 19 | empty |
| 5 | 89 | 0.35 | 0.75 | 20 | empty |
Interfaces
3 interfaces between chains.
- B–C · 702 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 383 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 287 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3EBM · Crystal structure of human translationally controlled tumour associated protein (hTCTP)… · the same entry in another collection · chain D against D, TM-score 1.00
- P13693 · AlphaFold monomer V2.0 prediction for translationally-controlled tumor protein (P13693) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13693
- Elsewhere: RCSB PDB 3EBM · PDBe 3EBM · UniProt P13693
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