Research workbench
Thermophilic P450: CYP119 from sulfolobus solfactaricus
Analyse Thermophilic P450: CYP119 from sulfolobus solfactaricus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1F4U
- Type
- protein
- Length
- 732 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450 119
- EC
- 1.14.14.-
- UniProt
- Q55080
- Ligands
- HEM, SO4
- Pockets
- 10 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cytochrome P450 119 (EC 1.14.14.-) | protein | 366 | 47% helix, 11% strand | Q55080 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
- IMD · Imidazole · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 677 | 0.84 | 0.88 | 66 | HEM, IMD |
| 2 | 668 | 0.84 | 0.88 | 67 | HEM, IMD |
| 3 | 291 | 0.60 | 0.78 | 34 | empty |
| 4 | 235 | 0.59 | 0.79 | 26 | empty |
| 5 | 230 | 0.58 | 0.79 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 555 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q55080
- Elsewhere: RCSB PDB 1F4U · PDBe 1F4U · UniProt Q55080
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.