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Crystal structure of the complex of murine gamma-herpesvirus 68 BCL-2 homolog M11 and the beclin 1 BH3 domain

Analyse Crystal structure of the complex of murine gamma-herpesvirus 68 BCL-2 homolog… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3DVU
Type: protein
Length: 309 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: V-BCL-2; Beclin-1
UniProt: P89884, Q14457

Structure

x-ray diffraction · 4 distinct chains · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	V-BCL-2	protein	130	71% helix, 0% strand	P89884
B	V-BCL-2	protein	131	66% helix, 0% strand	P89884
C	Beclin-1	protein	24	71% helix, 0% strand	Q14457
D	Beclin-1	protein	24	71% helix, 0% strand	Q14457

Interfaces

3 interfaces between chains.

B–D · 1037 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 1002 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 10 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3DVU · Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and the… · the same entry in another collection · chain B against B, TM-score 1.00
Q14457 · AlphaFold monomer V2.0 prediction for beclin-1 (Q14457) · a predicted model of the same protein · chain C against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P89884
Every structure of UniProt Q14457
Elsewhere: RCSB PDB 3DVU · PDBe 3DVU · UniProt P89884 · UniProt Q14457

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