Research workbench
Crystal structure of CA2+/CAM-CAV2.3 iq domain complex
Analyse Crystal structure of CA2+/CAM-CAV2.3 iq domain complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DVK
- Type
- protein
- Length
- 166 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Voltage-dependent R-type calcium channel subunit alpha-1E
- UniProt
- P62158, Q07652
- Ligands
- CA
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 143 | 60% helix, 3% strand | P62158 |
| B | Voltage-dependent R-type calcium channel subunit alpha-1E | protein | 23 | 78% helix, 0% strand | Q07652 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 365 | 0.62 | 0.78 | 47 | empty |
Interfaces
1 interface between chains.
- A–B · 1331 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3DVK · Crystal Structure of Ca2+/CaM-CaV2.3 IQ domain complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q07652 · AlphaFold monomer V2.0 prediction for voltage-dependent R-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt Q07652
- Elsewhere: RCSB PDB 3DVK · PDBe 3DVK · UniProt P62158 · UniProt Q07652
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