Research workbench
Structure of the catalytic subunit of telomerase, tert
Analyse Structure of the catalytic subunit of telomerase, tert in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DU6
- Type
- protein
- Length
- 1,192 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase
- UniProt
- Q0QHL8
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Telomerase reverse transcriptase | protein | 596 | 48% helix, 13% strand | Q0QHL8 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 629 | 0.76 | 0.82 | 62 | empty |
| 2 | 218 | 0.66 | 0.84 | 35 | empty |
| 3 | 214 | 0.66 | 0.84 | 36 | empty |
| 4 | 70 | 0.64 | 0.92 | 18 | empty |
| 5 | 87 | 0.62 | 0.88 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 876 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3DU6 · Structure of the catalytic subunit of telomerase, TERT · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q0QHL8
- Elsewhere: RCSB PDB 3DU6 · PDBe 3DU6 · UniProt Q0QHL8
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