UniProt Q0QHL8
Telomerase reverse transcriptase (Q0QHL8)
Telomerase reverse transcriptase (UniProt Q0QHL8), EC 2.7.7.49: 20 experimental structures on GenesisL1, 6 ligands bound, 52 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q0QHL8
- Protein
- Telomerase reverse transcriptase
- EC
- 2.7.7.49
- Experimental structures
- 20
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 52 · 6 records with a druggable one
Structures
20 records of Q0QHL8 in the MolNFT archive: 20 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3DU5 | Structure of the catalytic subunit of telomerase, TERT | x-ray diffraction | A, B | — | — |
| 3DU5 | Structure of the catalytic subunit of telomerase, tert | x-ray diffraction | A, B | — | — |
| 3DU6 | Structure of the catalytic subunit of telomerase, TERT | x-ray diffraction | A, B | — | — |
| 3DU6 | Structure of the catalytic subunit of telomerase, tert | x-ray diffraction | A, B | — | — |
| 3KYL | Structure of the catalytic subunit of telomerase bound to its RNA template and telomeric DNA | x-ray diffraction | A | — | — |
| 3KYL | Structure of the catalytic subunit of telomerase bound to its RNA template and telomeric DNA | x-ray diffraction | A | — | — |
| 5CQG | Structure of tribolium telomerase in complex with the highly specific inhibitor BIBR1532 | x-ray diffraction | A, B | — | — |
| 6E53 | Structure of TERT in complex with a novel telomerase inhibitor | x-ray diffraction | A | MG, HUV | 6 (best 0.80) |
| 6E53 | Structure of tert in complex with a novel telomerase inhibitor | x-ray diffraction | A | MG, HUV | — |
| 6USO | Telomerase Reverse Transcriptase prenucleotide binary complex, TERT:DNA | x-ray diffraction | A | MG | 8 (best 0.84) |
| 6USO | Telomerase reverse transcriptase prenucleotide binary complex, TERT:DNA | x-ray diffraction | A | MG | — |
| 6USP | Telomerase Reverse Transcriptase product complex, TERT:DNA | x-ray diffraction | A | MG | 11 (best 0.76) |
| 6USP | Telomerase reverse transcriptase product complex, TERT:DNA | x-ray diffraction | A | MG | — |
| 6USQ | Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA | x-ray diffraction | A | — | 7 (best 0.84) |
| 6USQ | Telomerase reverse transcriptase binary complex with Y256A mutation, TERT:DNA | x-ray diffraction | A | — | — |
| 6USR | Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp | x-ray diffraction | A | MG, G2P, K | 11 (best 0.84) |
| 6USR | Telomerase reverse transcriptase ternary complex, TERT:DNA:DGPCPP | x-ray diffraction | A | MG, G2P, K | — |
| 7KQM | Binary complex of TERT (telomerase reverse transcriptase) with RNA/telomeric DNA hybrid | x-ray diffraction | A | — | 9 (best 0.78) |
| 7KQM | Binary complex of tert (telomerase reverse transcriptase) with RNA/TELOMERIC DNA hybrid | x-ray diffraction | A | — | — |
| 7KQN | Ternary complex of tert (telomerase reverse transcriptase) with RNA template, DNA primer, an… | x-ray diffraction | A, D | CA, DGT | — |
Ligands
- MG · Magnesium ion · in 8 records
- G2P · Phosphomethylphosphonic acid guanylate ester · in 2 records
- HUV · methyl 1-{2-deoxy-5-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-D-erythro-pentofuranosyl}-1H-indole-5-carboxylate · in 2 records
- K · Potassium ion · in 2 records
- CA · Calcium ion · in 1 record
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 1 record
Elsewhere
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