Research workbench
Tarantula heavy meromyosin obtained by flexible docking to tarantula muscle thick filament cryo-EM 3D-MAP
Analyse Tarantula heavy meromyosin obtained by flexible docking to tarantula muscle… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DTP
- Type
- protein
- Length
- 2,566 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-11,MYOSIN-7; Myosin light polypeptide 6; Myosin II regulatory light chain
- UniProt
- P10587, P12883, P02607, B4XT43
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 4 distinct chains · 48% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-11,MYOSIN-7 | protein | 938 | 46% helix, 11% strand | P10587, P12883 |
| B | Myosin-11,MYOSIN-7 | protein | 940 | 50% helix, 10% strand | P10587, P12883 |
| C, D | Myosin light polypeptide 6 | protein | 148 | 54% helix, 7% strand | P02607 |
| E, F | Myosin II regulatory light chain | protein | 196 | 47% helix, 4% strand | B4XT43 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1084 | 0.83 | 0.84 | 97 | empty |
| 2 | 89 | 0.78 | 0.98 | 21 | empty |
| 3 | 903 | 0.76 | 0.79 | 91 | empty |
| 4 | 981 | 0.75 | 0.78 | 84 | empty |
| 5 | 287 | 0.74 | 0.87 | 38 | empty |
Interfaces
11 interfaces between chains.
- A–B · 5156 Ų buried · 59 hydrogen bonds · protein-protein
- B–F · 2591 Ų buried · 57 hydrogen bonds · protein-protein
- B–D · 2427 Ų buried · 37 hydrogen bonds · protein-protein
- A–E · 2322 Ų buried · 46 hydrogen bonds · protein-protein
- E–F · 1601 Ų buried · 45 hydrogen bonds · protein-protein
Compared structures
- 3DTP · Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick… · the same entry in another collection · chain F against F, TM-score 1.00
- P02607 · AlphaFold monomer V2.0 prediction for myosin light polypeptide 6 (P02607) · a predicted model of the same protein · chain C against A, TM-score 0.95
- P10587 · AlphaFold monomer V2.0 prediction for myosin-11 (P10587) · a predicted model of the same protein · chain B against A, TM-score 0.85
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain B against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10587
- Every structure of UniProt P12883
- Every structure of UniProt P02607
- Every structure of UniProt B4XT43
- Elsewhere: RCSB PDB 3DTP · PDBe 3DTP · UniProt P10587 · UniProt P12883 · UniProt P02607 · UniProt B4XT43
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