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Solution structure of a pro-apoptotic protein bax

Analyse Solution structure of a pro-apoptotic protein bax in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1F16
Type: protein
Length: 192 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (apoptosis regulator bax, membrane isoform alpha)
UniProt: Q07812
Pockets: 4 · best druggability 0.68

Structure

solution nmr · 1 distinct chain · 64% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (apoptosis regulator bax, membrane isoform alpha)	protein	192	64% helix, 0% strand	Q07812

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	112	0.68	0.90	36	empty
2	62	0.66	0.93	20	empty
3	141	0.64	0.86	25	empty
4	92	0.37	0.76	20	empty

Compared structures

1F16 · Solution structure of a pro-apoptotic protein bax · the same entry in another collection · chain A against A, TM-score 1.00
Q07812 · AlphaFold monomer V2.0 prediction for apoptosis regulator bax (Q07812) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07812
Elsewhere: RCSB PDB 1F16 · PDBe 1F16 · UniProt Q07812

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